What is oxycodone?
oxycodone acetaminophen 5-325 is used to manage pain severe enough to require an opioid pain medicine when other pain medicines do not treat pain well enough, or are not tolerated.
- Immediate-release formulations (tablets, capsules, oral solution) are used to treat severe pain when other medications are ineffective or not tolerated.
- Extended-release tablets manage persistent, severe pain requiring daily, long-term treatment and are not for “as-needed” use. Approved for adults and opioid-tolerant patients aged 11+ already taking at least 20mg oxycodone daily.Oxycodone can put you at risk for overdose and death. Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death.
The FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for opioid analgesics to balance benefits against risks of addiction and misuse. Prescribers must complete REMS-compliant education, counsel patients on safe use and disposal, ensure patients read Medication Guides, and consider patient-prescriber agreements to enhance safety.
Oxycodone is a full mu-opioid receptor agonist providing analgesia with no ceiling effect, meaning doses are limited only by adverse effects like respiratory and CNS depression. Its precise analgesic mechanism is unknown, but CNS opioid receptors throughout the brain and spinal cord are believed to be involved.
Important Information About Oxycodone
Get emergency help or call 911 right away if you take too much oxycodone (overdose). When you first start taking oxycodone, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose.
Taking oxycodone with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
Never give anyone else your oxycodone. They could die from taking it. Selling or giving away oxycodone is against the law.
How do I Take Oxycodone/oxycodone acetaminophen 5-325
When taking oxycodone, do not change your dose. Take oxycodone exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed.



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